"Major organs" refers to the important parts inside our bodies that perform specific functions necessary for our survival and overall health. These organs include the heart, lungs, liver, kidneys, and brain. Full definition
This characteristic means that it can be go in and out of major organs such as the brain, liver and nerves. (drjockers.com)
Major organ transplant: The receipt by transplant of any of the following organs or tissues: heart, lungs, liver, kidney, pancreas, or bone marrow. (phoenix.nsre.com)
Oral disease has been shown to affect general health especially the heart, kidneys and other major organ systems. (nevccc.com)