Decreased IGF type 1 receptor signaling in mammary epithelium during pregnancy leads to reduced proliferation, alveolar differentiation, and expression of insulin receptor substrate (IRS)-1 and IRS - 2. (dianaibclc.com)
Selective response to insulin versus insulin - like growth factor - I and - II and up - regulation of insulin receptor splice variant B in the differentiated mouse mammary epithelium. (dianaibclc.com)
When this model was in its softest mode, normal (benign) mammary epithelial cells behaved normally within it, forming cellular structures referred to as acini that capture many key features of the normal in vivo mammary epithelium. (sciencedaily.com)