According to the dynamic developmental behavioral theory proposed by Sagvolden et al, a hypofunctioning mesolimbic dopamine system is largely responsible for producing alterations in behavioral reinforcement and extinction, which, in turn, disrupts learning processes. (behavioralandbrainfunctions.biomedcentral.com)
Although antagonism of mesolimbic dopamine D (2) receptors by neuroleptics such as haloperidol attenuates positive symptoms of schizophrenia, a significant population of «resistant» patients fails to (semanticscholar.org)
The moderating effects of three single nucleotide polymorphisms (SNPs)(rs1042778, rs2268493 and rs237887) of the OXTR gene on mesolimbic responses to rewards were evaluated using a monetary incentive delay fMRI task. (molecularautism.biomedcentral.com)