Poggi A, Boero S, Musso A, Zocchi MR. Selective role of mevalonate pathway in regulating perforin but not FasL and TNFalpha release in human natural killer cells. (research.hsr.it)
In collaboration with the University of Texas Southwestern Medical Center (UTSW) in Dallas, the researchers found that the tumor - suppressive activity of geranylgeraniol was accompanied by down - regulation of HMG CoA reductase, a key enzyme in the mevalonate pathway that provides essential intermediates for the posttranslational modification of growth - related proteins such as Ras, nuclear lamins and insulin - like growth factor receptors. (sciencedaily.com)
The study, «P53 - and mevalonate pathway - driven malignancies require Arf6 for metastasis and drug resistance» by Ari Hashimoto and colleagues, has been published online ahead of print and suggests that statin - like drugs may be effective treatments for breast cancer patients whose tumors express high levels of Arf6 signaling proteins. (sciencedaily.com)