"Mismatch repair" refers to the process in our cells that fixes mistakes or errors that occur when DNA is being replicated. It helps to ensure that the new copies of our DNA are accurate and free from errors. Full definition
By contrast, not a single one of 25 colorectal patients lacking mutations in mismatch repair genes responded. (sciencemag.org)
The Hopkins group wondered if patients with many cancer types who had tumors with errors in mismatch repair genes would respond to PD - 1 inhibitors. (sciencemag.org)
The majority of cases of Lynch syndrome are attributed to heterozygous germline mutations in the DNA mismatch repair genes MLH1 and MSH2, and current methods for DNA sequencing and deletion analysis can successfully detect these mutations. (sciencedaily.com)