Promastigotes with reduced LMIT1 activity showed growth defects and were more susceptible to ROS toxicity, consistent with a role of iron as an essential co-factor of mitochondrial enzymes called superoxide dismutases that detoxify ROS. (sciencedaily.com)
Influence of endurance exercise training and sex on intramyocellular lipid and mitochondrial ultrastructure, substrate use, and mitochondrial enzyme activity (academic.oup.com)
The researchers performed the studies using mice bred to carry gene alterations that disrupt the production of the same mitochondrial enzyme that is defective in patients with MMA. (sciencedaily.com)