While there is a long - held theoretic belief of an increased risk of cancer, based on the growth hormone's antiapoptotic and mitogenic effects, neither long - term nor short - term data support this theory. (holtorfmed.com)
This is an example of simple mitogenic stimulation that has been in place since the 30s. (newscientist.com)
We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy. (lerner.ccf.org)