«Drosophila fly brings to light the role of morphogens in limb growth.» (sciencedaily.com)
Wnt proteins, regulators of development in many organisms, bind to seven transmembrane — spanning (7TMS) receptors called frizzleds, thereby recruiting the cytoplasmic molecule dishevelled (Dvl) to the plasma membrane.Frizzled - mediated endocytosis of Wg (a Drosophila Wnt protein) and lysosomal degradation may regulate the formation of morphogen gradients. (science.sciencemag.org)
In conclusion, my thesis work has shown that alterations in morphogen signaling landscapes underlie differences in tissue sizes. (science.sciencemag.org)