Conversion of fibroblasts into myofibroblast result from ROS - mediated accumulation of pro-angiogenic (HIF) and pro-inflammatory (SDF - 1 / CXCL - 12) components. (science.institut-curie.org)
They packed a cold - related virus called an adeno - associated virus, or AAV, with their transcription factors and used it to infect myofibroblasts in liver - damaged mice. (newscientist.com)
The researchers, led by Benjamin Humphreys, MD, PhD, found that a rare population of stem cells located outside of blood vessels in mice become myofibroblast cells that secrete proteins that cause scar tissue. (sciencedaily.com)