Moreover, disease - causing variants in DNA often do not act directly, but by activating nearby genes. (sciencedaily.com)
When Shi's group used the technique of RNA interference (RNAi) to reduce levels of the enzyme in human cells, specific histones were methylated and expression of nearby genes increased, the team reported in the 16 December online version of Cell. (sciencemag.org)
They identified three nearby genes responsible for transport in and out of the cell, and upon transferring these specific genes to E. coli, were able to produce an elusive TDA resistant bacterial strain. (sciencedaily.com)