We attributed false negatives to the possibility that the corresponding BC either did not harbor a mutation in any of these 11 genes or the fraction of neoplastic cells in the urine sample was insufficient to allow detection with the assays used. (elifesciences.org)
The frequency of neoplastic disease is strongly correlated with the relatively recent expansion of the human life span. (journals.plos.org)
The observations suggest strongly that genomic catastrophe can produce the required and necessary molecular alterations for neoplastic transformation and tumorigenesis in normal founder cells in the absence of selective pressures or ongoing genomic evolution.» (sciencedaily.com)