We carried out a non-complementation screen for new alleles of unc - 124 and identified four new mutations. (neuraldevelopment.biomedcentral.com)
So, if a gene lies within a gene - dense, low - recombination region, then this means that a much larger number of progeny from crosses must be examined to find those that derive from rare recombinational events that separate the desired new allele from undesirable forms of neighboring genes. (sciencedaily.com)
Besides ensuring correct chromosome segregation during the first meiotic division, crossovers create new allele combinations in gametes, thereby increasing genomic diversity, increasing the chance of creating offsprings with better phenotypic fitness, and providing the basis for faster evolution. (dresden-ipp.de)