We carried out a non-complementation screen for
new alleles of unc - 124 and identified four new mutations.
So, if a gene lies within a gene - dense, low - recombination region, then this means that a much larger number of progeny from crosses must be examined to find those that derive from rare recombinational events that separate the desired
new allele from undesirable forms of neighboring genes.
Besides ensuring correct chromosome segregation during the first meiotic division, crossovers
create new allele combinations in gametes, thereby increasing genomic diversity, increasing the chance of creating offsprings with better phenotypic fitness, and providing the basis for faster evolution.
Research at VetGen and independently at the University of Saskatchewan has identified two
new alleles in the E locus, Eg and Eh.
Their further analysis also provide evidence on the ancestral status of the Indian group, which holds great potential for
introducing new alleles into the cultivated gene pool.
Thereby, the model makes no assumptions about
how new alleles have been evolved, whether by drift or natural selection.
To continually produce more extreme variation despite these purifying forces requires the dog genome to create
new alleles at an extraordinary rate.
When Parham compared the HLA genes of people from different regions of the world with the Neanderthal and Denisovan HLAs, he found evidence that non-African humans picked up
new alleles from the hominins they interbred with.
Initially the people who drank milk from cows had something unusual about them, but by chance
the new allele improved the welfare of human beings on their way north.
Today, researchers are still trying to answer many questions about dominance relationships,
new alleles, gene series, modifying factors, etc..
Only after testing over 1600 PWDs did
a new allele that causes prcd - PRA come to light.