The blood stem cells are located in specialized niches in the bone marrow and are surrounded by specialized niche cells. (sciencedaily.com)
Looking further into the intestinal crypts of both the transgenic and wild - type mice, the research team made what they consider a surprising finding: Not only was HMGA1 causing the stem cells themselves to self - renew or proliferate more rapidly in the transgenic animals, but it was also increasing the number of Paneth cells, a type of niche cell known to support intestinal stem cells. (sciencedaily.com)
However, it is still unclear what type of niche cells make the Wnts and R - spondins. (sciencedaily.com)