Parkinson's disease (PD) is a progressive neurodegenerative disease characterised by motor and non-motor symptoms, resulting from the degeneration of nigrostriatal dopaminergic neurons and peripheral autonomic neurons. (link.springer.com)
«One possible explanation is that UPDRS reflects primarily deficits arising from nigrostriatal degeneration, whereas CSF α - synuclein levels are influenced by the whole brain and may serve as a proxy for total brain pathology,» says Dr. Zhang. (sciencedaily.com)
Unilateral nigrostriatal 6 - hydroxydopamine lesions in mice II: predicting l - DOPA - induceddyskinesia (neurostemcell.org)