the generation of novel mouse models of Cystic Fibrosis by exploring genetically - diverse murine populations that will provide unique tools for disease modeling and pre-clinical studies. (research.hsr.it)
We are also applying CRISPR / Cas9 - mediated genome engineering to develop novel mouse models in order to explore the impact of gene dosage alterations on tumor development in vivo. (cshl.edu)
Currently, the Hu lab continues to analyze the functions of ER proteins in malignant progression of leukemia using novel mouse models, in which we selectively deleted genes that encode critical ER - resident proteins that support the growth and survival of leukemia. (wistar.org)