In cancer, PAT function has been related to the amino acid - sensing engine that drives activation of the mammalian target of rapamycin complex 1 (mTORC1), which is an important target for existing and new anti-cancer drugs.» (sciencedaily.com)
Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function. (inmg.fr)
Next, we performed detailed histopathological assessments of the myocardium and the aortic vascular wall to identify possible effects of rapamycin on cardiovascular pathology associated with normal aging. (jci.org)