To determine whether SOST impacts metastasis in animals, they modified a prostate cancer cell line to overexpress SOST, engrafted various cells lines onto immunodeficient mice, and quantified the rate of secondary tumors and of osteolytic bone lesions. (sciencedaily.com)
Decreased metastasis by ABL - deficient breast cancer cells was accompanied by a significant reduction in the extent of hindlimb osteolytic lesions, as determined by x-ray and micro — computed tomography (μCT) imaging (Fig. 2, I and J). (stke.sciencemag.org)
These results demonstrate that ABL kinase activity is required for osteolytic metastasis in breast cancer and suggest that pharmacological inhibition of the ABL kinases may be an effective treatment for bone metastasis. (stke.sciencemag.org)