Previous research found that Short - root activates other transcription factors as well, creating a cascade in which each gene - regulating protein controls the next in the root development pathway. (sciencedaily.com)
So what we think is that probably in many cells in this section, all cells, the chromatin is encountered in a specific state, and in order to render the cell is permissive to reprogramming, you have to overcome these certain epigenetic modifications that block, for example, the binding of Ascl1 to its target chains, or the binding of other transcription factors to its target chains, then this way interfere with the possibility of reprogramming. (abcam.com)
They may exert a transcriptional function or act as comodulators for other transcription factors. (cancerres.aacrjournals.org)