When the scientists placed DIPG cells in the pons area of mice they found that systemic injections of panobinostat inhibited DIPG growth and extended survival. (sciencedaily.com)
Olesen R, Vigano S, Rasmussen T, Søgaard OS, Ouyang Z, Buzon M, Bashirova A, Carrington M, Palmer S, Brinkmann CR, Yu XG, Østergaard L, Tolstrup M, Lichterfeld M. Innate immune activity correlates with CD4 T cell - associated HIV - 1 DNA decline during latency - reversing treatment with panobinostat. (ragoninstitute.org)
Peter Atadja, a Ghanaian Drug Research and Development Scientist has led a team of researchers from Novartis Institute for Biochemical Research to develop Panobinostat (LBH - 589), an experimental drug for the treatment of cancers.LBH589 is a potent oral pan-inhibitor of class I, II, and IV histone (and non-histone) deacetylase enzymes (HDACs / DACs). (citifmonline.com)