There were large differences in the types and numbers of particular mutations found in different geographical areas. (genomel.org)
It also brings up crucial questions for future research: Scientists still don't know how particular mutations cause cancer, why they lead to cancer in some tissues and not others, or what might be done to counteract the mutations. (sciencemag.org)
With respect to antibiotic resistance, this novelty can be induced and we can trace the novelty to particular mutations arising absent gene transfer; i.e. the genes which give rise the resistance were not present prior to the mutation, they are new sequences and not simply the activation of dormant genes. (religion.blogs.cnn.com)