We selected seven genes of known physiological importance to the implantation to validate the RNA - seq results; five genes were associated with down - regulation of IFNT signaling in clones on gestation d18 (IFN.tau.c1, IFTN2, CXCL9, CXCL10, and IFI47), and two genes were up - regulated in d - 34 chorion from cloned samples (C3 and IL6). (pnas.org)
Surprisingly, none of the three suffers any apparent clinical consequence, which raises questions about the physiological importance of CHIP and implies that other mechanisms may compensate for its absence. (science.sciencemag.org)
«These discoveries demonstrate a hypothesis that we had made following a basic research study we had just carried out in our laboratory, and thus confirm the physiological importance of the unfolded protein response in the control of neurogenesis,» says Laurent Nguyen. (sciencedaily.com)