Then, the research group examined the molecular mechanism behind the impaired synaptic functions and behaviors in ARHGAP33 KO mice and found that ARHGAP33 is localized to the Golgi apparatus to regulate intracellular protein trafficking of the Tropomyosin receptor kinase B (TrkB) receptor, a neurotrophin receptor, to synaptic sites. (sciencedaily.com)
The beta - adrenergic receptor kinase (beta - ARK), which specifically phosphorylates only the agonist - occupied form of the beta - adrenergic and closely related receptors, appears to be important in mediating rapid agonist - specific (homologous) desensitization. (science.sciencemag.org)
Using the nanodiscs, the team elucidated the activation mechanism of receptor kinase AgrC and discovered a key regulatory hotspot in the kinase that could greatly affect its activity. (sciencedaily.com)