Südhof used genetic engineering to «knock - out» the synaptotagmin gene in mice, with the result that synapses from the forebrains of mice that lacked synaptotagmin lost their capacity for fast calcium - triggered release of neurotransmitter, thus confirming the importance of synaptotagmin in vivo. (kavlifoundation.org)
By blocking adenosine, caffeine increases the firing of neurons and release of neurotransmitters like dopamine and norepinephrine. (healthline.com)
And that increased release of neurotransmitters somehow makes it much easier to trigger a blackout.» (sciencedaily.com)