Target SNVs and indels across 47 driver genes with relevant mutations designed to cover a comprehensive set of myeloid disorders including acute myeloid leukemia (AML), myeloid dysplastic syndrome (MDS), myeloproliferative neoplasms (MPN), chronic myeloid leukemia (CML), chronic myelomonocytic leukemia (CMML), and juvenile myelomonocytic leukemia (JMML). (missionbio.com)
Using this approach, researchers can easily generate diseaserelevant isogenic models to determine the impact of correcting or introducing disease - relevant mutations on cellular phenotypes in a tissue - appropriate context. (sciencemag.org)
But «we didn't find any [relevant mutations] at all» in the Yellowstone wolves, Barsh recalls. (sciencemag.org)