Drobniewski's team found such mutations in more than 400 isolates that were resistant to the first - line antibiotic rifampicin, and the authors suggest that the mutations might overcome the growth - slowing effect of evolving resistance. (scientificamerican.com)
«The approach we're using should be able to create one or more analogs that could help take the place of rifampicin in TB therapy.» (sciencedaily.com)
When exposed to the front - line TB drug rifampicin, for example, Mtb cells lacking lamA were less able to survive than wildtype bacteria. (sciencedaily.com)