These assays have previously been used to probe deficits with scopolamine treatment [94 — 97]. (alzres.biomedcentral.com)
The acetylcholinesterase inhibitor, donepezil, which transiently improves cognition in AD, reverses the cognitive impairment induced by scopolamine in both humans and animals [92, 93]. (alzres.biomedcentral.com)
Mice were given J147 alone, donepezil alone and J147 + donepezil in food before the cognitive behavioral assays, including the Y - maze, a two - day water maze and fear conditioning were done in the presence of scopolamine treatment. (alzres.biomedcentral.com)