STAT5 belongs to a family of transcription factors that regulate cytokine - induced gene expression and is constitutively activated in several human cancers including breast cancer, where it promotes the expression of genes encoding cell survival factors (44). (stke.sciencemag.org)
Knocking out or blocking the activity of Nrp1 on regulatory T cells in mouse models of several human cancers, including the deadly skin cancer melanoma, led to reduced, delayed or complete elimination of the tumors. (stjude.org)
The extract was found to have cytotoxicity against several human cancer cell lines, while promoting apoptosis and cell cycle arrest. (groundedorganic.com)