A "short hairpin" refers to a small, U-shaped piece of metal or other material that is used to hold hair in place. It is typically shorter in length compared to regular hairpins. Full definition
Then, in Goga's UCSF laboratory, thousands of short hairpin RNAs (shRNAs), bits of genetic material that precisely shut down the activity of specific proteins, were sequentially introduced to the engineered cells — in this case, shRNAs targeting proteins called kinases, a common target of cancer drugs, were used. (sciencedaily.com)
The discovery of short hairpin RNAs (shRNAs) suppressing gene expression in mammalian cells enables large - scale loss - of - function screens by using genome - wide shRNA libraries. (mdanderson.ilabsolutions.com)
We have devised a massively parallel strategy for screening short hairpin RNA (shRNA) collections for stable loss - of - function phenotypes. (science.sciencemag.org)