The researchers found that strains of Mycobacterium smegmatis in which the genes for the hydrogenases or the regulator DosR had been «knocked out» experienced a hundredfold reduction in the long - term survival compared to the normal bacterium, he says. (sciencedaily.com)
Working with a non-pathogenic cousin of M. tuberculosis called M. smegmatis, the team used a mutant form of the bacteria that lacked the part of RbpA that interacts with fidaxomicin. (sciencedaily.com)
Professor Cook's team have established that Mycobacterium smegmatis metabolises molecular hydrogen using three enzymes called hydrogenases. (sciencedaily.com)