While scientists have long known that a group of transcription factors are needed for stem cell maintenance, the sheer number of possible interactions among them has made the question of which are essential too complicated to address in the laboratory alone. (the-scientist.com)
Furthermore, POSTN was reported to bind to Wnt ligands, leading to an increase in Wnt signaling in CSCs, a known regulator of stem cell maintenance in a variety of tissues (Malanchi et al., 2012). (elifesciences.org)
Research Paper Role of TRF2 in efficient DNA repair, spheroid formation and Cancer Stem Cell maintenance Arka Saha, SwatiShree Padhi, Madhabananda Kar, Shomereeta Roy, Prasanta Maiti, Birendranath Banerjee Oncomedicine 2017; 2: 71 - 79. (oncm.org)