Furthermore supraphysiological levels of many acidic hydrolases have no deleterious effect. (lysogene.com)
Moreover, increasing insulin concentrations could compensate for the reduced GS activity to a certain extent, whereas chronic supraphysiological insulin concentrations induced insulin resistance in GS and glucose transport activity. (diabetes.diabetesjournals.org)
In this study, we extended this picture further, since the compensatory effect of hyperinsulinemia on GS in diabetic cultures can be eliminated at supraphysiological insulin concentrations, which induce insulin resistance in diabetic as well as control cultures. (diabetes.diabetesjournals.org)