Aggregation of tau protein into intracellular deposits is a pathognomonic feature of tauopathies such as Alzheimer's disease (AD) and lowering tau is a prominent therapeutic strategy under development. (content.iospress.com)
P301L transgenic (tg) mice well mimic features of human tauopathies and provide a good model for investigating the role of tau in neurodegenerative events. (content.iospress.com)
Other scientists recently discovered that the Tau mutation in question could increase a person's risk of developing different tauopathies, including Alzheimer's or FTD. (gladstone.org)