«If a person is stable on narrow therapeutic index drug, it makes sense to think two times about changing to a generic or to a new brand - name drug,» Kesselheim says. (scientificamerican.com)
Although both forms are highly active, ADCs with alkylating IGNs demonstrated a better safety profile, and high therapeutic indices in vivo.23, 24 Here we describe the development and preclinical characterization of a novel CD123 - targeting ADC, IMGN632, consisting of a humanized anti-CD123 antibody conjugated to an alkylating IGN payload via a protease cleavable linker. (bloodadvances.org)
It's convenient and has a wide therapeutic index which makes this drench an exceptionally valuable product for parasite control in sheep. (jefferspet.com)