Transcriptional factors are proteins in our cells that control the activity of genes. They help to determine which genes are turned on or off, sending instructions to the cell about when and how to make certain proteins. Full definition
After receiving her Ph.D. in immunology from the Open University, United Kingdom, where she researched the identification of transcriptional factors regulating the unique phenotype of the human blood — brain barrier, she joined the Roche Brain Shuttle program as a postdoctoral fellow. (sciencemag.org)
Dillin's team then screened 15 other genes from the forkhead family — transcriptional factors important to development and possibly longevity, to which the gene for daf - 16 belongs — to see if any of them were necessary to increase longevity after dietary restriction. (scientificamerican.com)
Using this strategy, Cas9 is able to deliver transcriptional factors to specific genes and regulate their expression. (jax.org)