Many cancers are still difficult to treat and development of drugs exploiting new pathways and mechanisms involved in tumor initiation and malignant growth is of high priority [1]. (oncm.org)
Any deviation in these processes could lead to cells that do not have the proper number of chromosomes, which could accelerate tumor initiation and progression. (sciencedaily.com)
«In conclusion,» Nakano and fellow researchers wrote, «the FOXD1 - ALDH1A3 axis is critical for tumor initiation in mesenchymal GSCs, therefore providing possible new molecular targets for the treatment of GBM and other ALDH1 - activated cancers.» (sciencedaily.com)