Early observations suggesting that the virus might attack cancer in part by damaging blood vessels that feed tumor growth led the SillaJen team to strike up a collaboration with McDonald, an expert in tumor vasculature, to investigate the virus's mechanism of action in animal models. (ucsf.edu)
Rehemtulla adds that if other FDA - approved chemotherapeutic agents reach their targets as successfully as Photofrin did, «then we will have developed a way to make cancer drugs more «tumor - specific,» because they will only get into tumor vasculature and not normal vasculature. (scientificamerican.com)
As expected, trastuzumab distribution was heterogeneous and localized in the vicinity of tumor vasculature. (journals.plos.org)