This is in contrast to conventional biochemistry and molecular biology, which focuses on analyses of whole tissue samples and whole microbial populations or communities. (scilifelab.se)
A few years later, Karl Deisseroth's lab developed CLARITY, which is a hydrogel - based method that also allows antibody penetration for immunohistochemical labeling in whole tissue (15). (blog.addgene.org)
[25] Seeing that in metastatic patients the only available tumor is often core biopsies rather than whole tissue blocks, we next attempted to determine whether the degree of heterogeneity varies between primary and metastatic sites, using the TMA cores as surrogates for core biopsy specimens. (jcancer.org)