However, the offspring of these adults, when reared in hypoxic conditions showed less ability to regulate their oxygen uptake and were significantly smaller than those of normoxic parents, potentially because they were having to expend more energy simply to survive in those conditions. (sciencedaily.com)
In addition, temporal [17] and spatial [16,17] correlations between increased levels of HIF - 1α, the regulatory subunit of HIF - 1, and increased VEGF expression have been shown, indicating that HIF - 1 may control the expression of VEGF in the retina under hypoxic conditions. (molvis.org)