«Yeast spotlights genetic variation's link to drug resistance: Study shows that genetic diversity influences
which adaptive mutations cause antimicrobial resistance.»
«The ‡ Khomani San have the largest genetic diversity of any living population,» Alpert Sugden said, «which is interesting from our perspective because there's a lot of opportunity
for adaptive mutations to arise.»
Despite the fact that TLM B cells generally divided more frequently than their RM counterparts, researchers found that the antibodies derived from TLM B cells showed genetic evidence of
fewer adaptive mutations than those derived from RM B cells.
In addition, analysis of the chikungunya virus strain expressing a combination of the second -
wave adaptive mutations revealed a similar pattern of changes and heightened adaptive qualities suggesting the future emergence of even higher transmission efficiency.
Over the very period that the brain shrank, our DNA accumulated
numerous adaptive mutations related to brain development and neurotransmitter systems — an indication that even as the organ got smaller, its inner workings changed.
A decade earlier, in 1988, a group of molecular biologists led by John Cairns at the Harvard School of Public Health published startling results showing
similar adaptive mutations.
They find an abundance of
recent adaptive mutations etched in the human genome; even more shocking, these mutations seem to be piling up faster and ever faster, like an avalanche.
Bianconi I, Milani A, Cigana C, Paroni M, Levesque RC, Bertoni G, Bragonzi A. Positive signature - tagged mutagenesis in Pseudomonas aeruginosa: tracking patho -
adaptive mutations promoting airways chronic infection.
While most techniques identify only regions of the genome likely to
contain adaptive mutations, SWIF (r) can also identify the particular mutations themselves.
Using a new machine learning approach, researchers at Brown's Center for Computational Molecular Biology
found adaptive mutations in metabolic genes in a group of African hunter - gatherers.
Antibiotic Resistance, Houston, TX, USA presentation «
Adaptive Mutations in LiaR are Sufficient to Confer Daptomycin Resistance in E. faecium by Inducing Phosphorylation - Independent Activation of the LiaFSR - mediated Membra...
«Despite the experimental data provided here, it is impossible to clearly establish whether
the adaptive mutations observed were in part responsible for the extended duration of the 2013 — 16 epidemic,» they write in their paper.
To show that the technique works, the researchers validated it on a simulated dataset in which known
adaptive mutations were included, as well as on canonical adaptive mutations that have been identified in human genomes through multiple molecular experiments.
These adaptive mutations can spread quickly (evolutionarily speaking) through a population in subsequent generations, a process known as a selective sweep.
SWIF (r) was shown to outperform both individual statistical techniques and other composite techniques in picking out
those adaptive mutations, while producing a lower rate of false positives.