An important impact of the Hematopoietic Stem - Cell Gene Therapy described in the paper, is that it allows for the use of autologous CD34 + cells, thereby avoiding complications associated
with allogeneic transplantation.
Hutter G and Thiel
E Allogeneic transplantation of CCR5 - deficient progenitor cells in a patient with HIV infection: an update after 3 years and the search for patient no. 2.
Peripheral blood stem cells are generally used in autologous transplantations, while either marrow or peripheral blood stem cells are used
in allogeneic transplantations.
This has great impact on patient care as over the past few decades many patients have suffered from engraftment problems and graft versus host disease associated
with allogeneic transplantation.
HSCT is effectively used today as a form of «replacement» therapy for patients with hard - to - treat blood cancers, providing healthy cells from either the patient (autologous transplantation) or from a donor (
allogeneic transplantation) to better equip patients to fight the disease on their own.
In contrast, injections of the cells into immunologically unmatched recipients (called
an allogeneic transplantation) caused the body to mount a stronger immune response.
Somewhat sparsely described in the book is the vast clinical use of adult hematopoietic stem cells in autologous and
allogeneic transplantation.