Sentences with phrase «allosteric modulators»
Allosteric modulators are substances that can control how proteins work. They can attach to a protein in a place that is different than where other substances usually attach, and change the protein's shape or activity. This can either increase or decrease the protein's function, making allosteric modulators useful for regulating key processes in the body. Full definition
Administration of a positive allosteric modulator of the type 1 metabotropic glutamate receptors mGluR1 during the first postnatal week restored DA neuron excitatory synapse transmission and partially rescued the social preference defects, while optogenetic DA neuron stimulation was sufficient to enhance social preference.
inb.u-bordeaux2.fr
With Jan Stichel at Annette Beck - Sickinger's lab, Leipzig University, Germany and David Weaver, head of the high - throughput screening facilities at Vanderbilt University, I will be screening Vanderbilt's library of small molecules for potential allosteric modulators of the human Y4 receptor.
The PI of the proposal has also experience in cheminformatics method development for chemical biology and therapeutic development (Mueller, R., et al.; «Discovery of 2 -(2 - Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor 5 (mGlu5): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound»; ChemMedChem; 2012; 7; 406).
Medical researchers are increasingly studying positive allosteric modulators because they target secondary drug receptor sites in the body.
His work helped discover a class of molecules called core protein allosteric modulators, or CpAMs, that disrupt capsid protein assembly.
Title: Selective Remediation of Reversal Learning Deficits in the Neurodevelopmental MAM Model of Schizophrenia by a Novel mGlu5 Positive Allosteric Modulator Author: F. Gastambide et al..
Muscarinic receptor M4 positive allosteric modulators attenuate central effects of cocaine...
• Alfred J, Uberti M, Dovlatyan M, Li Z, Smith D, Weiss J, Jubian V, Grenon M, Li G, Doller D and Brodbeck R: The Synthesis and invitro pharmacology of the selective mGLUR5 negative allosteric modulator (NAM).
The project aims to discover new agonist, antagonist and allosteric modulators of these receptors mostly orphans.
The research, which appears in the journal Biological Psychiatry, finds that the use of compounds called positive allosteric modulators, or PAMs, enhances the effect of pain - relief chemicals naturally produced by the body in response to stress or injury.
The findings indicate that compounds known as positive allosteric modulators, or PAMS, can increase the natural pain - relief chemicals produced by the body in response to injury.
One particular focus in our work is structure, dynamics, and interactions of G - Protein Coupled Receptors (Wu, H.; et al. «Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator»; Science; 2014; 58 or Alexander, N.; et al. «Energetic analysis of the rhodopsin - G - protein complex links the alpha5 helix to GDP release»; Nat Struct Mol Biol; 2014; 56).