Sentences with phrase «amyloid deposits»
"Amyloid deposits" refers to the buildup of abnormal proteins called amyloid in certain tissues of the body. These deposits can occur in various organs and may interfere with their normal function, often leading to disease or damage. Full definition
As treatments aimed at reducing amyloid deposits have proved unsuccessful, other treatment approaches are needed.
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The researchers did not study the mechanism for how cholesterol promotes amyloid deposits.
The authors said this finding is compatible with an increase in amyloid deposits in the brain; the finding was confirmed in the subset of participants who underwent amyloid PET, which showed an increase in amyloid burden in those with OSA.
AD mice treated with NR had lower degrees of amyloid deposits, improved mitochondrial energy production, and improved memory.
RESULTS: Neither neuropathological nor biochemical examinations showed amyloid deposit in the brain of this immunized patient.
He added that the purpose of this study was to investigate the associations between OSA severity and changes in AD biomarkers longitudinally, specifically whether amyloid deposits increase over time in healthy elderly participants with OSA.
Because PIB selectively binds to brain amyloid deposits but quickly clears from normal tissue, the chemical dye accurately indicates the amount of protein that is deposited in the living brain.
The impact on amyloid deposits was studied histologically.
Affected cats developed amyloid deposits primarily in their kidneys resulting in chronic kidney disease typically before they were 6 years of age.
This idea of targeting beta amyloid deposits in the brain to clear them out is known as the «amyloid hypothesis.»
They found that the test reliably detected amyloid - beta alterations in the blood of participants with mild cognitive impairment that also showed abnormal amyloid deposits in brain scans.
Amyloid deposits also appear to be abnormal in patients with SVD, especially in (APOE) Ɛ4 carriers.
«If modifying cholesterol levels in the brain early in life turns out to reduce amyloid deposits late in life, we could potentially make a significant difference in reducing the prevalence of Alzheimer's, a goal of an enormous amount of research and drug development effort.»
They found that IVIg lowers amyloid deposits in the brains of the mice over the course of seven days.
After 54 weeks, positron emission tomography brain scans revealed that those who had received the drug had fewer β amyloid deposits; the higher the dose, the greater the reduction in β amyloid.
Scientists have long used an imaging technique called positron emission tomography (PET) to visualize ß - amyloid deposits marked by radioactive chemical tags in the brains of people with AD.
This image shows tau - positive neuron (black) in proximity to amyloid deposits within blood vessels (red) in an aged chimpanzee brain.
A team of scientists at Sweden's Linköping University have developed a molecular probe that can detect an array of different amyloid deposits in several human tissues.
As the disease progresses and amyloid deposits grow, tissues become irreversibly damaged.
However, evidence from the Linköping team, presented in the journal Amyloid show that their new probe is much more sensitive, being able to detect small amyloid deposits in samples that were previously determined to be amyloid - free.
Like other pathologists in countries where people had died of CJD associated with medical procedures, he rushed to check the centre's archives of autopsied brains to see if any of them contained the ominous amyloid deposits.
Image analysis of the immunohistochemical studies displayed in A (staining with an anti-IAPP antibody) was performed to estimate the percentage of islets containing amyloid deposits (E) and the load of IAPP aggregates (F), calculated as the percentage of the stained area compared with the total islet area.
These results suggest that material containing aggregated IAPP seeds can induce the aggregation and deposition of new IAPP amyloid in cultured islets and that the formation of new amyloid deposits depends on the expression of endogenous hIAPP in the islets.
Although a considerable amount is known about the structure of the protein within the Parkinson's - typical amyloid deposits, nothing was known about its original state in the healthy cell up to now.
But there are other possible explanations, including the activity of apolipoprotein E (APOE), a substance known to regulate amyloid deposits.
Now, a spinal tap or PET scan can detect the telltale amyloid deposits, and researchers are trying to develop a simple blood test that would do so.
One interpretation could be that the intracellular pool of Aβ may act as a source for the formation of extracellular amyloid deposits [14].
Amyloid deposits first appear in the kidneys of affected cats between 9 months and 2 years of age.
Musen would like to employ amyloid imaging in type 2 diabetic patients to determine whether amyloid deposits are present in their brains.
During autopsies, researchers found that their brains had the lowest amount of amyloid deposits and contained the most antibodies.
The relationship between elevated cholesterol and increased risk of Alzheimer's disease has been known for some time, but the current study is the first to specifically link cholesterol to amyloid deposits in living human study participants, Reed said.
ß - amyloid deposits can damage many organs besides the brain, including the heart, liver, and kidneys, says neuroscientist Rudolph Tanzi of Massachusetts General Hospital (MGH) in Boston, a leader of the new study.
The UK researchers set out to investigate the mechanism by which the treatment may act in the brain to lower amyloid deposition (amyloid deposits being a key pathology in Alzheimer's).
«Several studies have suggested that sleep disturbances might contribute to amyloid deposits and accelerate cognitive decline in those at risk for AD,» said Ricardo S. Osorio, MD, senior study author and assistant professor of psychiatry at New York University School of Medicine.
«Generally, the groups performed equally well in the tasks, but it turned out that for people with beta - amyloid deposits in the brain, the more detailed and complex their memory, the more brain activity there was,» said Jagust.
Previous studies have shown a link between increased brain activity and beta - amyloid deposits, but it was unclear whether the activity was tied to better mental performance.
What remains unclear, said Jagust, is why some people with beta - amyloid deposits are better at using different parts of their brain than others.
Brain scans showed that 16 of the older subjects had beta - amyloid deposits, while the remaining 55 adults did not.