Sentences with phrase «aneuploid cells»

However, telomerase, the enzyme, which can synthesize telomeres, may also support the survival of aneuploid cells by alleviating telomere induced stress signals in response to aneuploidy.

Pre-malignant aneuploid cells grew more slowly and formed smaller tumors than comparable cells with normal chromosome number.»

Having an irregular number of chromosomes, almost by definition, leads to imbalances in the numbers of proteins expressed in aneuploid cells.

Pre-malignant aneuploid cells grew more slowly and formed smaller tumors than comparable cells with normal chromosome number, CSHL researchers found...

This is what the team observed in some of their cultured aneuploid cells.

We demonstrated that aneuploidy can function as a novel source of genomic instability, as aneuploid cells tend to display elevated levels of mutation, mitotic recombination, and chromosome loss.

Wing primordia subjected to CIN are characterised by tumor - like overgrowths, metastatic behavior and malignancy to the host upon blockade of the apoptotic machinery, and this tumorigenic response relies mainly on the production of highly aneuploid cells that delaminate from the epithelium and activate a JNK - dependent transcriptional response.

Using a series of genetically - matched euploid and aneuploid cell lines, we have demonstrated that aneuploidy can paradoxically function as a barrier to tumor growth.

By identifying phenotypes that are shared among tumors with different aneuploidies, we hope to discover pathways that can be manipulated to selectively eliminate aneuploid cells or to block aneuploidy's non-cell autonomous effects.

For example, Berman says, future treatments might combine antifungal drugs with compounds still to be developed that can hinder the formation of aneuploid cells.

Moreover, when the pre-malignant aneuploid cells were injected into rodents, they consistently formed smaller tumors than the pre-malignant cells with normal chromosome numbers.

Sheltzer will continue to explore the evolution of aneuploid cells, including the question of whether the rapid evolution seen in pre-malignant cells might account for their subsequent ability to resist chemotherapy.

«We think this rapid evolution could allow the aneuploid cells to acquire some of the pro-cancer characteristics that might promote cancer development or cause a cancer in a person to proliferate,» Sheltzer says.

The accumulation of such problems over time, he says, may be triggering the inflection point in the aneuploid cells» growth that his team reports in the experiments published today.

«We noticed that the aneuploid cells would start out growing very poorly.

Telomeres respond to aneuploidy by generating stress signals that suppress the proliferation of aneuploid cells.

All five had a high percentage of aneuploid cells, and two already have cancer.

These aneuploid cells usually die, but every so often the new genetic arrangement — called the karyotype — might enhance a cell's ability to survive and clone itself.

Mouse model of chromosome mosaicism reveals lineage - specific depletion of aneuploid cells and normal developmental potential.

Further we showed that elimination of aneuploid cells is dependent on the activity of p53.

Cole Laboratory publishes new paper in Cell (10/19/2017)- Chromosome mis - segregation creates cells with the wrong number of chromosomes (aneuploid cells).