Sentences with phrase «areas of the genome»

Analysis also revealed a number of «off - target» mutations assumed to be caused by the technique acting in other areas of the genome.

It is used today primarily by gene hunters and other researchers who focus on specific areas of the genome.

These behavioral tests helped the team identify brave and anxious birds, then narrow down areas of the genome related to variations in anxiety.

A genetic study has found areas of the genome linked with the age at which people have sex for the first time.

Rather it flags areas of the genome that contribute to risk.

One strength of this unbiased approach is that highly diverse areas of a genome can be made accessible.

The genes had broad functions including controlling the expression of genes in many other areas of the genome.

In addition, many of the copy number variations turned up in areas of the genome once considered «junk DNA.»

They found four key areas of the genome where specific SNPs correlate with skin color.

«DNA sequencing is a powerful tool, but it is still quite expensive and has several technological and functional limitations that make it difficult to map large areas of the genome efficiently and accurately,» says Jason Reed, Ph.D., principal investigator on the study.

In the study now published in the scientific journal Nature the researchers have compared the genomes in a large number of dogs and wolves, and mapped areas of the genome that show clear differentiation between the two groups.

«We've narrowed down the search to a small area of the genome» that confers resistance, Anderson notes.

As the cell replicates its DNA, it must also preserve the epigenetic marks that delineate active and inactive areas of the genome.

Researchers investigated the glycophorin area of the genome in more detail than before using new whole - genome sequence data from 765 volunteers in the Gambia, Burkina Faso, Cameroon and Tanzania.

These regions can be clumped into larger areas of the genome called quantitative trait loci, which are known to contain genes that produce a specific physical effect, such as shaggy hair.

The hypothesis that human evolution is accelerating «all rests on being able to identify recent areas of the genome under natural selection fairly accurately,» says human geneticist Jonathan Pritchard of the University of Chicago.

This suggests that it is chromatin's packing density, and not some higher - order structure, that determines which areas of the genome are active and which are suppressed.

To avoid these problems, the team used sequence data to create a list of single DNA letter changes, known as SNPs, which can be reliably identified in the gene - rich areas of the genome.

It also raises new questions about how these large changes can be brought about: possibly new mechanisms, perhaps even new machineries that are necessary to change certain areas of the genome» reflects Graf.

On closer inspection, the scientists discovered that the three genes involved in producing miR135 are located in areas of the genome that are known to be associated with risk factors for bipolar mood disorders.

Finally, they compared the genomes of people from around the world and found more genetic variation in the genomic regions that control facial characteristics than in other areas of the genome, a sign that variation is evolutionarily advantageous.

It builds on a 2011 discovery by Berman and Laird that first determined loss of these DNA marks — called methyl groups — occurs in specific areas of the genome in cancer.

It scans a very broad area of the genome (508 genes and more than two million base pairs or letters of the genome, i.e.. A, T, C, and G) with high accuracy (each region of the genome is sequenced or «read» 60,000 times), yielding about 100 times more data than other sequencing approaches.

«Methylation patterns drift steadily throughout life, with methylation increasing in some areas of the genome, and decreasing in others,» says Dr. Issa.

In Europe and China, a series of large - population studies confirmed that mutations in the area of the genome controlling MHCI increase the risk of schizophrenia.

Any methylation in these areas of the genome might therefore impact future generations — and could provide the missing clue for how a person can pass on hereditary changes caused by their environment to their children and grandchildren.

«By identifying the areas of the genome that are directly involved in the reprogramming, we have also identified an important factor in the process — the gene regulatory protein KLF11 (Kruppel Like Factor - 11), which is found in all fat cells, and we have shown that it is required for the reprogramming to take place.»

Researchers have previously harnessed this system to create gene - editing complexes composed of a DNA - cutting enzyme called Cas9 and a short RNA that guides the enzyme to a specific area of the genome, directing Cas9 where to make its cut.

It is a crucial network in the nucleus, providing mechanical support to the nucleus and also regulating gene expression by making some areas of the genome less or more available to be transcribed into messenger RNA.

The areas of the genome and the factors that control whether or not the information is read, in total, are referred to as the cell's regulome.

The area of the genome related to immunity contains hundreds of genes, some of which affect other aspects of biology.

In this area of the genome the researchers then identified three genes as the most associated with the development of glioma in dogs.

According to Dr. Burgess, the team is now working to extend the period that sperm cells can be cultured, so there is more time to select cells that have the foreign gene inserted in specific areas of the genome in what is commonly called a «targeted gene knockout.»

Scientists at The Institute of Cancer Research, London, looked in detail at 63 areas of the genome that had previously been associated with the risk of breast cancer by mapping studies.

They've also provided dozens of other areas of the genome that they believe could be of note.

The locus sits close to an area of the genome where humans and chimps are known to share specific combinations of genes.

There are a few other things that make the area of the genome in question — called a locus — particularly intriguing.

«The genetic change around that area of the genome changes the risk of getting malaria.»

Searching through these genes, Moxon has identified a set of «contingency genes,» which contain a region with a higher rate of mutation than other areas of the genome.

Areas of the genome that are highly variable are assembled using the default reference sequence at this time.

It provides support to keep the shape of the nucleus and also regulates DNA replication by making some areas of the genome less (restricted) or more (permissive) available to be translated into proteins.

An international speaking panel will bring together top researchers in the areas of genome wide scanning (GWS), the major histocompatability complex (MHC), genetic testing, genetic counseling, and specific genetic disorders of cats and dogs.

For example, in my area of genome editing, there are huge amounts of data produced at every step in a given process, and data science helps a scientist apply that data in the laboratory.