Sentences with phrase «axon regeneration»
Axon regeneration refers to the process where damaged or injured axons (long nerve fibers) in the body's nervous system can grow and repair themselves. It allows the nerves to rebuild connections and restore their proper function. Full definition
In Aim 2, we will examine whether the rate and pattern of axon regeneration in these knockout mice are affected.
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The study, «Facilitation of axon regeneration by enhancing mitochondrial transport and rescuing energy deficits,» which has been published in The Journal of Cell Biology, suggests potential new strategies to stimulate the regrowth of human neurons damaged by injury or disease.
We are further exploring the molecular network in which the Tsc proteins function, and have found that modulation of the growth - promoting mTOR pathway, which is regulated by TSC proteins, can promote axon regeneration in the adult central nervous system.
The discovery opens up plenty of new avenues of research, including investigations into guidance mechanisms of other classes of axons along the longitudinal axis (Nature Neuroscience, 2005; 8: 1151 - 1159) and axon regeneration following injury.
During his doctoral and post-doctoral work under the mentorship of Jeffrey Goldberg, MD, PhD, and Larry Benowitz, PhD, Dr. Trakhtenberg discovered (1) how Set - β and PP2A proteins regulate axon growth; (2) the role of serotonin receptor 2C in neurite growth and processing of visual information; and (3) that inhibiting the transcription factor Klf9 acts synergistically with zinc chelation in stimulating axon regeneration.
What his group found is that not only does that promote axon regeneration all the way back down the nerve, but in fact those axons go back to the right areas that they're supposed to get to in the brain — the right brain nuclei — and restore some measures of visual function.
For example, it has long been known that astrocytes within glial scar tissue contribute to the failure of axon regeneration across sites of traumatic brain or spinal cord injury [1]--[6].
In this study, we will examine whether glial cells and certain proteins secreted from these cells influence axon regeneration and guidance in the optic nerve in adult mice.
His laboratory at Stanford University School of Medicine is developing novel stem cell and nanotherapeutics approaches for ocular repair, studying retinal ganglion cell development, survival and axon regeneration in glaucoma, and investigating the cellular basis for the developmental loss of axon growth ability.
In contrast, overexpression of ctgfa resulted in increased bridging, axon regeneration and overall healing.
But exploring the role of PPM - 2 in controlling DLK - 1 and axon regeneration could be worthwhile — and could have implications in neurodegenerative diseases.»
The study describes how RPM - 1 regulates the activity of a single protein known as DLK - 1, a protein that regulates neuron development and plays an essential role in axon regeneration.
«Scar formation has long been considered the principal impediment to axon regeneration.»
«Maybe it's not surprising that a highly evolved central nervous system wound response, such as scar formation, would play a crucial beneficial function in both wound healing and axon regeneration,» he said.