Bioinformatics analysis refers to the process of using computer software and algorithms to study biological data, such as DNA sequences or protein structures. It helps researchers understand and interpret complex biological information, aiding in the discovery of patterns, similarities, and important features that can provide insights into various aspects of biology.
Full definition
As a part of VIOLIN, we have developed Vaxign, the first web - based publically available vaccine target design tool based on
bioinformatics analysis of genome sequences using the strategy of reverse vaccinology.
We report unbiased metagenomic detection of chikungunya virus (CHIKV), Ebola virus (EBOV), and hepatitis C virus (HCV) from four human blood samples by MinION nanopore sequencing coupled to a newly developed, web - based pipeline for real - time
bioinformatics analysis on a computational server or laptop (MetaPORE).
Viral discovery is performed on human, animals, biologics, and environmental samples using viral particle enrichment, random nucleic acid amplification, and deep sequencing followed by
bioinformatics analysis for the presence of viral sequences.
Data access and analysis tools are being made available for the 3K RGP dataset through the International Rice Informatics Consortium (IRIC), which promotes collaboration
in bioinformatics analysis of rice data and provides computational tools to facilitate rice improvement via discovery of new gene - trait associations and accelerated breeding.
Identification of a human papillomavirus - associated oncogenic miRNA panel in human oropharyngeal squamous cell carcinoma validated
by bioinformatics analysis of the Cancer Genome Atlas.
We report unbiased metagenomic detection of chikungunya virus (CHIKV), Ebola virus (EBOV), and hepatitis C virus (HCV) from four human blood samples by MinION nanopore sequencing coupled to a newly developed, web - based pipeline for real -
time bioinformatics analysis on a computational server or la
Although no functions could be assigned to three of the proteins,
bioinformatics analysis suggested that the remainder are involved in a wide range of biological processes, including reproduction, cellular metabolic processes, multicellular organismal growth, developmental processes, growth, locomotion, response to stimuli, localization and biological regulation.
Using this «Ribotag» approach tissue - specific changes under DR have been measured in muscle, fat, gut, heart, neurons, germline and malpighian tubules, showing a highly tissue specific response upon DR.. We are developing mechanistic models of gene expression regulation and conducting
comprehensive bioinformatics analyses on UTRs, promoters and the coding sequences of various elements of differentially regulated genes.
In small cell lung cancer, starting
from bioinformatics analyses of large gene expression datasets, we clustered subsets of co-expressed gene modules, derived networks of transcription factors and simulated their dynamics using logic - based mathematical modeling.
CLC Genomics Server is a software solution for deployment on your central compute cluster or compute server for
centralized bioinformatics analysis and sharing of data generated from all High - Throughput Sequencing platforms.
The researchers combined protein purification techniques including fast protein liquid chromatography, with modern metagenomics, metaproteomic and
associated bioinformatics analyses.
In the laboratory, the research team replicated human colorectal cancer in pre-clinical experiments and
used bioinformatics analysis to demonstrate that a low - dose of the chemotherapy drug decitabine targeted the cancer stem cells by inducing viral mimicry.
Next, the contents of the normal and stress - exposed exosomes were characterized and compared using various molecular and cellular biologic techniques, proteomics analysis followed
by bioinformatics analyses.
Data access and analysis tools are being made available for the 3K RGP dataset through the International Rice Informatics Consortium (IRIC), which promotes collaboration in
bioinformatics analysis of rice data and provides computational tools to facilitate rice improvement via discovery of new gene - trait associations and accelerated breeding.
Genomic annotations are the focal point of sequencing,
bioinformatics analysis, and molecular biology.
«Dental calculus is a window into the past and may well turn out to be one of the best - preserved records of human - associated microbes,» says Professor Christian von Mering, an author of the study and Group Director at the SIB Swiss Institute of Bioinformatics, which performed the bioinformatics analysis
Using next - generation sequencing,
bioinformatics analysis and mathematical modeling performed by Maxim Imakaev in Leonid Mirny's lab, the researchers identified specific patterns that emerge during genome reorganization in mouse oocytes and zygotes.
The sequencing data and
bioinformatics analyses will help identify genetic markers that could be used to monitor these genes and determine their public health relevance.
The gene sequencing was performed at SNP&SEQ Technology Platform at SciLifeLab and
the bioinformatics analysis were partly performed at the SciLifeLab Bioinformatics Platform.
A key program of VIOLIN is Vaxign, the first web - based publically available vaccine target design tool based on
bioinformatics analysis of genome sequences using the strategy of reverse vaccinology.
Yue Lu, Ph.D., assistant professor of Molecular Carcinogenesis, performed
the bioinformatics analysis.
This workshop includes genome annotation as part of the NSF - funded MaizeCODE Project (Red Line), species identification by DNA barcoding and
bioinformatics analysis (Blue Line), RNA - Seq analysis (Green Line), and the new Purple Line — a user - friendly implementation of the QIIME 2 software for microbiome analysis.
Are you planning a project and need someone to discuss
the bioinformatics analysis with?
BSRI is equipped with an Illumina MiSeq and a high - performance computing platform for
bioinformatics analyses, an example of which can be seen here.
Systems biology and
bioinformatics analyses are employed to compare research results from model organisms with human aging to develop models and predictions for causative molecular mechanisms and circuits that influence human aging.
The synthetic lethal pairs initially found in our screens are extensively validated using both, in vitro experiments and
bioinformatics analysis.
Our bioinformatics analysis, based on multiple independent large - size cohorts shows that MELK is strongly overexpessed in BBC / TNBC, not only compared to normal breast tissues, but also compared to luminal or ER / PR + breast cancer.