Sentences with phrase «cell source»

They argue that there is a realistic alternative stem cell source for cell therapy.

Stem cells are the most favorable cell source for cell therapy, due to their inherent self - renewal properties and differentiation potential.

Previous studies have demonstrated the bone - forming potential from other cell sources, yet serious caveats for clinical translation remain.

Therefore, the need for research with human embryonic stem cells still exists despite the availability of new cell sources, the guidelines say.

Doctors look at a variety of factors when determining which cell source is best for a patient.

My lab is interested in the development of tissue models from human stem cell sources.

So far, two major endogenous cell sources for neuronal regeneration have been described: the Müller glia (MG) and retinal pigment epithelial (RPE) cells.

International and regional organizations collect the numbers of transplants annually by disease, donor type, and stem cell source from countries known to perform HSCT in World Health Organization (WHO) member states.

Bone marrow was initially the only stem cell source available until the 1990s when peripheral blood stem cells (PBSCs) and cord blood began to be used.

Colonization and osteogenic differentiation of different stem cell sources on electrospun nanofiber meshes.

In the several years since those first reports, new advances in the derivation of hiPSCs from various tissue sources (including those from human patients) and using diverse reprogramming techniques, and in their use as a pluripotent cell source in the induced differentiation of a wide array of somatic cell types, have appeared with almost startling rapidity.

Current methods, producing stem cells from adult somatic cells, offer an alternative cell source for transplantation.

Recently, scientists developed a procedure for generating pituitary cells from human pluripotent stem cells — an unlimited cell source for regenerative medicine — using organoid cultures that mimic the 3D organization of the developing pituitary gland.

Donor type and stem cell source differed between regions.

So, autologous cells derived from the patient can be used to treat devastating neurogenic diseases that are currently hampered by the lack of easily accessible cell sources.»

Researchers assessing the cardiac differentiation potential of several adipose - derived stem cells describe an optimal cell source

Scaffold - cell bone engineering in a validated preclinical animal model: Precursors vs differentiated cell source.

It will focus on catalyst development for four applications: proton exchange membrane fuel cells to convert stored energy in non-fossil fuels into electricity; electrolysers for splitting water into oxygen and hydrogen — a potential clean fuel cell source; syngas, a mixture of CO and H2, which is generated from coal, gas and biomass, and widely used as a key intermediate in the chemical industry; and lithium - air batteries.

Numerous cell sources can be utilized for cell therapies: embryonic stem cells (ESCs) isolated from the inner cell mass of the blastocyst, fetal stem / progenitor cells (FSCs) isolated from fetal tissues, adult stem / progenitor cells (ASCs) or primary cells derived from adult tissues, and induced pluripotent stem cells (iPSCs) reprogrammed from somatic cells under specific conditions.

While originally these treatments took the form of allogeneic bone marrow transplants, more recent breakthroughs in the field have provided cell therapy researchers with methods for correcting genetic mutations in a patient's own cells to provide an autologous source of HSCs for transplant, or to expand cells ex vivo and extend the potential of allogeneic cell sources.

Possible solutions can be provided by use of MSCs, which are known for their immunomodulatory properties, iPSCs, which are derived from the patient's own tissue, and of course autologous cell sources.

The routine use of MSC cellular therapy with would benefit from a uniform cell source, with stable phenotype and function as well as providing a solution to potential safety issues.

The successful differentiation of iPS cells into RPE represents a significant advance in the search for a potential cell source for the treatment of human neural retinal diseases.

Review of «Footprint free human iPSCs from articular cartilage with redifferentiation capacity - a first step towards a clinical grade cell source» from Stem Cell Translational Medicine by Stuart P. Atkinson

Patient - specific Induced pluripotent stem cells (iPSCs) are the obvious choice, and the group of Anders Lindahl from the Institute of Biomedicine at Sahlgrenska Academy, University of Gothenburg, Sweden have previously utilised modified synthetic messenger RNAs [4] to reprogram chondrocytes from donors undergoing ACI to chondrocyte - iPSCs (C - iPSCs) delivering both an invaluable cell source for cell replacement therapy and for disease modelling (e.g. Osteoarthritis).

«Report on the National Eye Institute Audacious Goals Initiative: Replacement of Retinal Ganglion Cells from Endogenous Cell Sources,» by Monica Vetter and Peter Hitchcock, Translational Vision Science & Technology, March 2017.

Our platform includes two distinct approaches to create these vaccines: AST - VAC1, an autologous (patient - specific) vaccine based on cells sourced from the patient, and AST - VAC2, an allogeneic (non-patient specific) vaccine manufactured from our proprietary pluripotent stem cell platform.

Exploitation of alternative cell sources (xenogeneic primary islets, stem cell derived beta cells) for utilization in our encapsulation device (collaboration with Anthony Gavalas, CRTD)

Consequently, adult stem therapies require a stem cell source of the specific lineage needed and harvesting and or culturing them up to the numbers required is a challenge.

Ultimately, we use all this information to establish innovative culture techniques for generating unlimited neural stem cell sources for the derivation of specific types of clinically relevant neuronal or glial cells, for their use in disease modelling and drug discovery platforms, and towards refining their efficacy for future cell replacement - based therapy.

Having generated a cell source and overcome the safety concerns associated with transplanting stem cells, researchers still face possibly their biggest challenge: showing that the transplanted photoreceptors wire up to other neurons that eventually connect to the optic nerves.

Stem cell source: With rats, Niklason has relied on lung cells from other animals to repopulate the scaffold.

Stem cell source: Obtained from skin or blood cells of patients.

Stem cell source: Temple obtains her raw materials from eye banks.

Stem cell source: Bursac obtains muscle through a biopsy, soaks the cells in a cocktail of factors and then adds some to a 3 - D environment, a hydrogel that mimics the geometrical shape of a blood clot.

«The advances in transplant techniques and the range of available cell sources that can be used to optimize the treatment of aberrant corneal wound healing can give reassurance to patients with corneal injuries that preserving vision may be possible in the near future,» wrote the authors of the Stem Cells review.

Of these HSCTs, the stem cell sources were bone marrow (54 percent), PBSC (41 percent), and cord blood (5 percent).

Ayami Yoshimi, M.D., Ph.D., of the University of Freiburg, Germany, and colleagues examined the use of peripheral blood stem cells and bone marrow as stem cell sources for hematopoietic stem cell transplantation in patients with bone marrow failure worldwide and factors associated with the use of each stem cell source.

The gross national income per capita and stem cell source had a weak but significant association.

Currently, PBSCs are the major stem cell source, owing to faster engraftment and ease of collection despite a higher rate of graft - vs - host disease and lower survival rates in patients with nonmalignant disorders.

The resulting 2724 trials were then categorized and core information collated, including: trial phase, cell source (autologous / allogeneic), current activity of the trial and responsible national regulatory agency.

A new study describes an improved protocol for the efficient differentiation of endothelial cells from pluripotent stem cell sources and highlights the importance of the MAPK and PI3K signaling pathways

Retinal regeneration by de-novo neurogenesis, a damage induced process by endogenous cell sources, is well established in retina of some species, like fish and chick, but does not occur spontaneously in mice and humans.

Cells sourced from fat are already inflamed, and inflammation is a major contributor to the aging process,» Dr. Maharaj said.

Are cord blood transplants more tractable for children than for adults in terms of the amount of cord blood that's needed for a transplant relative to other stem cell sources?

«Now that we know a fetus can become tolerant to a foreign stem cell source, we can really think big and consider looking at how other types of stem cells might be used to treat everything from neurological disorders to muscular disorders before birth,» MacKenzie added.

Cell sourcing for bone tissue engineering: Amniotic fluid stem cells have a delayed, robust differentiation compared to mesenchymal stem cells.

The TRANSEURO trial of fetal ventral mesencephalic cell grafts has already implanted cells in its first patient, using improved patient selection, cell sourcing, and graft techniques.

ASCs isolated from the stromal vascular fraction of fat have advantages over other mesenchymal stem cell sources; they are easy to isolate and expand and aid in the repair of damaged tissues [7], including islet graft survival and revascularization [8].