Sentences with phrase «change in genes»

The aging process is accompanied by changes in gene expression.

It explains how changes in gene activity can occur without changing our actual DNA.

Evolution occurs at the microscopic level by changes in genes as a result of the survival of the most adapted organisms for the environment in which they live.

Are behavioral differences primarily due to changes in gene regulation or structure?

Next, the team plans to validate their computational framework as a tool to assess changes in gene function in other biological contexts, such as in other diseases and tissues.

Researchers say that future studies could look at how changes in these genes may bring about this risk of — or resilience — to brain injury.

So the capacity of an organism to adapt to an environment is mediated through epigenetic changes in gene expression.

Within the cell, they can trigger changes in gene expression and biochemical reactions, among other things.

Even small changes in gene activity can change cell behavior dramatically, so this fine - tuning may open up new avenues for studying gene function.

The high risk for congenital heart defects in this group provides a tool to identify changes in genes, both on and off chromosome 21, which are involved in abnormal heart development.

Certain changes in genes or chromosomes may cause medical problems.

DNA breaks may lead to permanent changes in the genes, at worst causing cancer.

The ability to interpret the significance of a rare change in a gene depends on how well the function of that gene is understood.

The early stages of animal development are characterized by dramatic changes in gene expression.

The results suggest that subtle changes in gene dosage across many genes, caused by the change in chromosome numbers, can promote alternate behaviors.

The findings provided evidence in support of the differential susceptibility hypothesis and shed light on the potential for dynamic change in gene - environment interactions over development.

To defeat cancer, we need a therapy that does not depend on anything that a cancer could escape through a mutation - driven change in gene expression.

These animals also showed corresponding changes in genes in their spinal cord.

The most notable changes in gene activity were related to stress response and immune function.

Usually it's a bad thing to have too much change in a gene, and natural selection gets rid of it.

Then, she was more interested in the rapid change in gene expression patterns stimulated by environmental stress, which is anything but subtle.

However, the other 50 % of these families do not carry any of the known mutations (harmful changes in a gene).

As the worms aged, the team observed dramatic changes in gene expression.

The first direct evidence has been found linking smoking to epigenetic changes in genes that help fight cancer.

Small changes in genes, called mutations, can have major consequences.

Researchers add that future studies could look at how changes in these genes may bring about this risk of - or resilience - to brain injury.

In the grand scheme the differences between the two creatures are just adjustments to a basic body plan, and such adjustments, we are assured by evo devo, are the result of changes in gene regulation, not a complete new suite of genes.

Abnormalities in the structure of chromosomes are known to cause changes in gene expression during development of nerve cell networks.

Similarly, caffeine also appears to have the capacity to induce changes in the gene expression of important transcription factors that are involved in EE.

These variants cause significant changes in gene expression in a human neuroblastoma cell line, likely due to disrupted transcription factor binding.

It is not clear which exact biomarker or combination of biomarkers is responsible for changes in the gene expression as there is a lot happening in the intestinal soup.

The aim of WICT is the removal from the organismal environment of accumulated cellular and intracellular damage present in the patient's endogenous cells, including telomere depletion, nuclear DNA damage and mutations, mitochondrial DNA damage and mutations, replicative senescence, functionally - deleterious age - related changes in gene expression and accumulated cellular and intracellular aggregates.

Triple - negative cancer is the most common type of breast cancer found in women with changes in a gene called BRCA1.

Finally, because we did not measure gene expression, the current results await replication and extension using methods that can clarify whether the observed effects are associated with changes in gene expression that would indicate up or down regulation of TNF.

One of the crucial adaptations involved changes in a gene that encodes a viral protein used to enter cells.

Knowing this, Dr. Soliman and colleagues decided to search the DNA of ALTS patients for specific changes in genes associated with scarring and wound healing.

Gaucher works on developing computational methods of detecting the creation of original proteins from changes in gene sequences and hopes to use a combination of computational, evolutionary, and structural methods to locate sites on genomes where mutations or copy errors may create new proteins.

They found similar changes in gene expression in the same genes with increased activity of glucose transporters in both the stem cells and the fat cells, Sen noted.

The statement emphasises that the speed of change in gene sequencing technology has far outpaced regulation, or universally accepted guidelines.

Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence.

«But they are the first empirical demonstration in higher primates that evolution may often work through changes in gene regulation.»

Three recent studies found that people with a single nucleotide base change in the genes that code for cell receptors that bind nicotine — the addictive chemical in cigarettes — were more likely to develop lung cancer (ScienceNOW, 2 April).

Dr Gilchrist said: «This study suggests that we may improve significantly on the widely used analysis methods for determining gene expression levels from high throughput sequence data: absolute quantitation offers a much sounder basis for determining changes in gene expression level, a measure widely used to determine the consequence of genetic, chemical or physical disturbances in living systems.»

An abnormal change in gene structure / mutation of the MTHFR gene can cause a disruption of the MTHFR enzyme's normal function of breaking down -LSB-...]

Various bat species that emit high - frequency squeaks to detect prey and avoid obstacles share a high degree of variation in the FOXP2 gene, according to a new study, suggesting that genetic changes in the gene helped promote the evolution of this ability.