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A better understanding of the causes of SIDS is needed to identify infants at high risk and to develop interventions and guidelines that will prevent SIDS for all infants... Overall, the evidence is compelling that variants of SCN4A with disruption
of channel function are overrepresented in SIDS.»
An international team of scientists was able to demonstrate in mouse and patient studies, how magnesium affects the production of blood platelets and that the
TRPM7 channel function plays a key role in this process.
For example, the identification of highly specific and potent CFTR inhibitors has led to a number of studies examining the role of CFTR ion
channel function in basic physiological processes.
Alternatively, genetic methods can be used, typically involving Cre - recombinase (Cre)- mediated excision of a loxP flanked exon in Grin1, which encodes a critical NMDA - R subunit that is required
for channel function.
In addition, a computer simulation demonstrated that the compromised sodium
channel function caused abnormalities in an electrocardiogram, which was similar to abnormalities in patients.
Structures of water channels AQP0 and AQP4 were analyzed by electron crystallography and appear to play a role in cell adhesion in addition to
water channel functions.
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The Temple researchers recreated these mutated channels and showed that one resulted in a loss
of channel function.
Further studies in animal models and patients (with altered
TRPM7 channel function) have been initiated, in order to evaluate the efficacy and safety of magnesium as a therapeutic for this disease.
Vascular smooth muscle cells isolated from ERβ - deficient mice show multiple abnormalities of
ion channel function.
«We know dysregulation of a protein enzyme called multifunctional CaM kinase II plays a role in disrupting
sodium channel function in cardiac disease, but it was a matter of determining how this occurred and whether we could we prevent it for therapeutic benefit,» said Hund, an associate professor of biomedical engineering at The Ohio State University.
Researchers manipulated
the channel function of TRPM7 in megakaryocytes of mice and observed severe damages in the structure of platelets, the so - called cytoskeleton.
«But then I thought, what if I could make an antibody that interferes with
the channel function?»